Electro spinning of Polycaprolactone / Hydroxyapatite Composites in Wound Dressing Application
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Polycaprolactone polymer is widely used in medical applications due to its biocompatibility. Electro spinning was used to create poly (ε- caprolactone) (PCL) nanocomposite fiber mats containing hydroxyapatite (HA) at concentrations ranging from 0.05 to 0.4% wt. The chemical properties of the fabricated bio composite fibers were evaluated using FTIR and morphologically using field-emission scanning-electron microscopy (FESEM), Porosity, contact angle, as well as mechanical testing(Young Modulus and Tensile strength) of the nanofibers were also studied. The FTIR results showed that all the bonds appeared for the pure PCL fiber and the PCL/HA nano fibers. The FESEM nano fiber showed that the fiber diameter increased from 54.13 to 155.79 (nm) at the HA values from (0.05 % and 1%wt.).
Porosity, wettability of (PCL/HA) composites has improved, and the contact angle has decreased from 103.59o to 85.57o for fibrous scaffolds. The inclusion of hydroxyapatite increased the tensile strength of nano fiber scaffolds, and the maximum tensile strength of 0.4% percent was about 0.127 MPa, with a lowering in elongation to 40%.
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© 2023 The Author(s). Published by College of Science, University of Baghdad. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
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Labrique A.B., Wadhwani C., Williams K.A., Lamptey P., Hesp C., Luk R., and Aerts A., Best practices in scaling digital health in low and middle income countries. Globalization health, 2018. 14(1): pp. 1-8.
Xiao B., Huang Q., Chen H., Chen X., and Long G., A fractal model for capillary flow through a single tortuous capillary with roughened surfaces in fibrous porous media. Fractals, 2021. 29(01): pp. 1-10.
Kazsoki A., Farkas A., Balogh-Weiser D., Mancuso E., Sharma P.K., Lamprou D.A., and Zelkó R., Novel combination of non-invasive morphological and solid-state characterisation of drug-loaded core-shell electrospun fibres. International Journal of Pharmaceutics, 2020. 587: pp. 1-8.
Ahmadian A., Shafiee A., Aliahmad N., and Agarwal M., Overview of nano-fiber mats fabrication via electrospinning and morphology analysis. Textiles, 2021. 1(2): pp. 206-226.
Li S. and Lee B.K., Electrospinning of circumferentially aligned polymer nanofibers floating on rotating water collector. Journal of Applied Polymer Science, 2020. 137(22): pp. 1-9.
Khorshidi S., Solouk A., Mirzadeh H., Mazinani S., Lagaron J.M., Sharifi S., and Ramakrishna S., A review of key challenges of electrospun scaffolds for tissue‐engineering applications. Journal of tissue engineering regenerative medicine, 2016. 10(9): pp. 715-738.
Islam M.S., Ang B.C., Andriyana A., and Afifi A.M., A review on fabrication of nanofibers via electrospinning and their applications. SN Applied Sciences, 2019. 1(10): pp. 1-16.
Samadian H., Mobasheri H., Hasanpour S., and Faridi Majidi R., Electrospinning of polyacrylonitrile nanofibers and simulation of electric field via finite element method. Nanomedicine Research Journal, 2017. 2(2): pp. 87-92.
Chen S., Boda S.K., Batra S.K., Li X., and Xie J., Emerging roles of electrospun nanofibers in cancer research. Advanced healthcare materials, 2018. 7(6): pp. 1-20.
Shi C., Dai J., Li C., Shen X., Peng L., Zhang P., Wu D., Sun D., and Zhao J., A modified ceramic-coating separator with high-temperature stability for lithium-ion battery. Polymers, 2017. 9(5): pp. 1-12.
Yun B.J., Kwon J.E., Lee K., and Koh W.-G., Highly sensitive metal-enhanced fluorescence biosensor prepared on electrospun fibers decorated with silica-coated silver nanoparticles. Sensors Actuators B: Chemical, 2019. 284: pp. 140-147.
Júnior L.P., Silva D.B.d.S., de Aguiar M.F., de Melo C.P., and Alves K.G., Preparation and characterization of polypyrrole/organophilic montmorillonite nanofibers obtained by electrospinning. Journal of Molecular Liquids, 2019. 275: pp. 452-462.
Balogh A., Farkas B., Pálvölgyi Á., Domokos A., Démuth B., Marosi G., and Nagy Z.K., Novel alternating current electrospinning of hydroxypropylmethylcellulose acetate succinate (HPMCAS) nanofibers for dissolution enhancement: The importance of solution conductivity. Journal of pharmaceutical sciences, 2017. 106(6): pp. 1634-1643.
Mochane M.J., Motsoeneng T.S., Sadiku E.R., Mokhena T.C., and Sefadi J.S., Morphology and properties of electrospun PCL and its composites for medical applications: A mini review. Applied Sciences, 2019. 9(11): pp. 1-17.
Hassan M.I. and Sultana N., Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane. 3 Biotech, 2017. 7(4): pp. 1-9.
Standard A., Standard test methods for apparent porosity, water absorption, apparent specific gravity, and bulk density of burned refractory brick and shapes by boiling water. West Conshohocken, PA.: ASTM C20-00, 2015.
Zareanshahraki F., Jannesari A., and Rastegar S., Morphology, optical properties, and curing behavior of UV-curable acrylate-siloxane polymer blends. Polymer Testing, 2020. 85: pp. 1-12.
ASTM A., D882-18, standard test method for tensile properties of thin plastic sheeting. Annual Book of American Standard Testing Methods American Society for Testing Materials: West Conshohocken, PA, USA, 2018. 8: pp. 182-190.
Samadian H., Salehi M., Farzamfar S., Vaez A., Ehterami A., Sahrapeyma H., Goodarzi A., and Ghorbani S., In vitro and in vivo evaluation of electrospun cellulose acetate/gelatin/hydroxyapatite nanocomposite mats for wound dressing applications. Artificial cells, nanomedicine, biotechnology, 2018. 46(sup1): pp. 964-974.
Wunner F.M., Maartens J., Bas O., Gottschalk K., De-Juan-Pardo E.M., and Hutmacher D.W., Electrospinning writing with molten poly (ε-caprolactone) from different directions–Examining the effects of gravity. Materials 2018. 216: pp. 114-118.
Eichholz K.F. and Hoey D.A., Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing. Acta biomaterialia, 2018. 75: pp. 140-151.
Johari N., Fathi M., Fereshteh Z., Kargozar S., and Samadikuchaksaraei A., The electrospun poly (ε‐caprolactone)/fluoridated hydroxyapatite nanocomposite for bone tissue engineering. Polymers for Advanced Technologies, 2020. 31(5): pp. 1019-1026.