Preparing Mesoporous Alumina as a Delivery System for the Ciprofloxacin Drug using the Microemulsion Method

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Received: Jan. 14, 2025 Revised: Apr. 12, 2025 Accepted: May 3, 2025 Published: 01-12-2025
DOI: https://doi.org/10.30723/ijp.v23i4.1421
Keywords:
Microemulsion, Mesoporous Alumina, Ciprofloxacin, Drug Delivery, Release Profile

Main Article Content

Hayder J. Mohammed
Scientific Research Commission, Baghdad, Iraq
Sameer H. Kareem
Department of Chemistry, College of Science, University of Science for Women, Baghdad, Iraq

Abstract

Two samples of γ–mesoporous alumina (0.3M/m-Al2O3 and 0.5M/m-Al2O3) were prepared using the microemulsion method, with aluminium sulphate serving as the alumina precursor. The raw materials for microemulsion are sodium dodecyl sulphate (SDS) as the surfactant, 1-butanol as a cosurfactant, and n-hexanol as the oil phase. Scanning Electron Microscopy (SEM), BET surface area, BJH porosity of the samples, and their N2 adsorption-desorption isotherms at 77 K. The X-ray diffraction (XRD) and AFM techniques were used to characterize these samples. The results show that the two samples have identical phase structures and perfect indexing to the γ-Al2O3; the 0.3M/m-Al2O3 sample has a larger surface area, 229.18 m2 g-1, pore diameter, 5.59 nm, and pore volume, 0.32 cm3.g-1, than the 0.5M/m-Al2O3 sample. The morphology of the two samples was small spherical particles aggregated in spherical agglomerates, but the 0.3M/m-Al2O3 sample displayed smaller particles than the 0.5M/m-Al2O3 sample; the percentage of aluminium oxide was high, equal to 95.5% and 97.3% by weight for the 0.3M/m-Al2O3 and 0.5M/m-Al2O3, respectively. As a model, the 0.3M/m-Al2O3 sample was used as a carrier for delivering the ciprofloxacin drug. The loading was performed using the impregnation method, while the release was achieved through a dialysis bag with buffer solutions at pH levels of 7.4 and 5.4. The results indicate that the sample can serve as a suitable carrier for the ciprofloxacin drug.

Received: Jan. 14, 2025 Revised: Apr. 12, 2025 Accepted: May 3, 2025

Article Details

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Vol. 23 No. 4 (2025)

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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

© 2023 The Author(s). Published by College of Science, University of Baghdad. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License. 

How to Cite

1.
Mohammed HJ, Kareem SH. Preparing Mesoporous Alumina as a Delivery System for the Ciprofloxacin Drug using the Microemulsion Method. IJP [Internet]. 2025 Dec. 1 [cited 2025 Dec. 1];23(4):159-68. Available from: https://ijp.uobaghdad.edu.iq/index.php/physics/article/view/1421

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